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Vitamin B12 deficiency has been linked to fatigue, tingling or loss of feeling in the extremities, irritability, memory impairment, depression, anemia, irritable bowel syndrome (IBS), constipation, poor wound healing, dry or damaged looking skin, and neurological disorders

This increase in energy can support more active lifestyles and exercise, which is a key component of weight loss

This was because the drug did not significantly reduce weight in 536 subjects over the course of 24 weeks 2

The needle is inserted at a 45-degree angle, just below the skin, as opposed to deep into a muscle

Also, patients should be warned about the danger of taking folic acid in place of vitamin B12, because the former may prevent anemia but allow progression of subacute combined degeneration